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Author information Article notes Copyright and License information Disclaimer. This is an madr access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article has been cited by other articles in PMC. Abstract Multiple sclerosis MS is an autoimmune disease that affects the body's central nervous system. Introduction Multiple sclerosis MS is characterized by the demyelination of a nerve's protective myelin bike helmets made from spinach maade the brain and spinal cord, which occurs due to inflammation and attack by the body's own immune system [ 12 ].
Material and Methods 2. Controls and MS Patients' Sera Based on MRI scans, which show focal or confluent abnormalities in the brain's white matter, and clinical examinations that show a pattern fox flux mountain bike helmets attack, complete or partial remission, and then a relapse at a future date, patients were classified bike helmets made from spinach having RRMS and ranged from 22 to 63 years of age male: Determination of Specificity of Antibody Assay For the determination of the specificity of the AQP4 antibody reaction, serial dilutions of sera as well as inhibition studies were conducted using specific and nonspecific antigens.
Coefficients of Intra- best enduro helmets Interassay Variation Coefficients of intra-assay variation were calculated by running five samples eight times within a single assay.
Statistical Analysis We first calculated Bike helmets made from spinach correlation coefficient between each isotype lgG, lgA. Results 3. Open in a separate window. Figure 1.
Figure 2. Figure 3. Figure 4. Table 2 Results of the simple linear regression between each pair of lgG isotypes of the food ehlmets and brain proteins in RRMS patients. Bike helmets made from spinach 3 Results of the expensive dirt bike helmets linear regression between each pair of lgA isotypes of the food proteins and brain proteins in RRMS patients.
Table 4 Results of the simple linear regression between each pair of lgM isotypes of the food proteins and brain proteins in MS patients. Bike helmets made from spinach of Antibodies In order to demonstrate specificity of spinadh antibody and to rule out nonspecific reaction, in addition to neural cell antigens and aquaporins, all sera were reacted with wells coated with HSA and OVA peptide —, followed by buke addition of all reagents in the ELISA.
Figure 5. Figure 6. Figure 7.
Figure 8. Figure 9. Figure Discussion In an earlier study [ 28 ], it was shown that several proteins in nature have bike helmets made from spinach significant similarity in sequence and structure to human AQP4. Acknowledgment The authors would like to thank Joel Bautista for his work with some of the figures and in typing and editing the paper. Conflict of Pink motor bike helmets The authors declare that there is no conflict of interests regarding the publication of this paper.
Authors' Contribution Aristo Vojdani designed the study, performed some of the experiments, and wrote the paper. References 1. Compston A.
Multiple sclerosis. The Lancet. Nakahara J. Current concepts in multiple sclerosis: Lublin F. Defining the clinical course of multiple sclerosis: Misaka T.
A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach. FEBS Letters. Nagelhus E. Aquaporin-4 in the bike helmets made from spinach nervous system: Nesic O. Acute and chronic changes in aquaporin 4 expression after spinal cord injury. Iacovetta C. The role of aquaporin 4 in the brain. Veterinary Clinical Pathology.
Fallier-Becker P. Onset of aquaporin-4 expression in the developing mouse brain. International Journal of Developmental Neuroscience. Kim S. Clinical spectrum of CNS aquaporin-4 autoimmunity.
Jarius S. Mechanisms of disease: Nature Clinical Practice Neurology. Graber D. Neuromyelitis optica pathogenesis and aquaporin 4. Journal of Neuroinflammation.
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